Marine Natural Products (MNPs)

Natural products (NPs) have been widely scrutinized by researchers as an important source of emerging drug discovery. The chemical diversity of NPs is more closely related to drugs, thus making them ideal candidates for drug discovery programs. Recent studies have shown that the diversity of marine organisms, microbial complexity, and unique marine environment provides a wide range of potential drugs with excellent chemical novelty for most of the untapped ones, and about 30,000 marine natural products (MNPs) have been identified. Studies on the potential use of microbial communities (bacteria, actinomycetes, cyanobacteria, and fungi), microalgae, macroalgae (seaweeds), invertebrates, sponges, soft corals, and sea fans in cancer therapy have been reported.

Figure 1. Examples of marine natural products and derivatives that are in advanced clinical trials. (Jiménez C, 2018)

Functions of Our MNPs

MNPs are metabolites of marine organisms, especially natural products from certain algae, with antimicrobial activity have unsaturated chains, and usually have halogens attached to oxygen-containing heterocyclic rings. MNPs have structural diversity and a variety of potential biological activities such as anticancer, anti-inflammatory, anti-tumor, anti-malarial, anti-viral, anti-bacterial, and anti-fungal, which play an important role in the value of MNPs as lead compounds in the clinical medication of human diseases. In addition, MNPs are a critical source of bioactive agents. People have extracted various compounds from marine organisms such as periphyton, sponges, soft corals, and mollusks that can regulate various bioactivities.

Classification of MNPs Compounds

• Polysaccharides
• Polyether
• Macrolides
• Peptides
• Unsaturated fatty acids
• C15 acetogenins
• Steroids
• Alkaloids
• Terpenoids
• Prostaglandin analogs

So far, a series of compounds of MNP extracted from different marine organisms such as aglycone adenosine (Ara-A), aglycone cytosine (Ara-C), Ascidian-1, Ziconotide, eribulin, and dolastatin have become novel antiviral and antitumor marine drugs, which have been widely used in human eye herpes simplex virus infections, neurological biology research and cancer therapy.

Our Products

• MNPs derived from marine microorganisms
• MNPs derived from sponge
• MNPs derived from marine algae
• MNPs derived from other marine organisms

CD BioSciences is a leading marine biotechnology services company dedicated to providing customers with high-quality and abundant marine natural products for drug discovery and disease research in the biomedical field. If you are interested in our products, please feel free to contact us.

Reference

• Jiménez C. (2018). Marine natural products in medicinal chemistry[J]. ACS medicinal chemistry letters. 9(10): 959-961.

Please kindly note that our products can only be used to support research purposes (Not for clinical use).