Pain is a normal protective mechanism of the body and a common symptom of many clinical diseases. Commonly used drugs, such as morphine and aspirin, have good curative effects on chronic pain, neuropathic pain, and inflammation, but their toxic and side effects have always been a bottleneck and have not been significantly improved. For example, morphine has a serious addiction, tolerance, respiratory distress, and a series of adverse reactions. Research shows that marine natural products (MNPs) have analgesic biological activity and have become one of the main sources of drug development. With the deepening of global research on natural medicines and marine medicines, CD BioSciences has made remarkable achievements in the field of analgesic drug development using MNPs with its professional scientific research team and advanced R&D technology.

Marine natural products are used in the R&D of analgesic drugs for treating pain.Figure 1. Marine invertebrates producing anticancer and analgesic drugs. (Molinski T F, et al., 2009)

Classical MNPs and Analgesic Function

  • Conotoxins. Conotoxins are a class of peptide toxins extracted from marine Conus, which are highly selective and potent neurotoxicity. They can target neuronal ion channels and receptors, interfere with nerve signal transmission, and treat severe chronic pain.
  • Astaxanthin. It is a carotenoid extracted from microalgae and marine organisms that has potent antioxidant and anti-inflammatory effects. Research shows that astaxanthin can reduce pain and inflammatory reactions by inhibiting inflammatory factors and oxidative stress.
  • Polysaccharides. For example, fucoidan from brown algae and Carrageenan from red algae have been shown to have anti-inflammatory and analgesic potential. These polysaccharides can relieve pain by inhibiting the release of inflammatory mediators and regulating immune responses.
  • Metabolites of marine microorganisms. Studies have demonstrated that a large number of marine actinomycetes and fungi produce different types of secondary metabolites with analgesic and anti-inflammatory activities.

What Can We Offer?

  • Sample Collection and Storage

We cooperate with multiple marine institutions and have a rich resource library to collect various biological samples from the ocean. In addition, we use advanced preservation techniques to ensure sample freshness and integrity.

  • Extraction and Purification

We use advanced extraction technology to achieve efficient extraction of natural products from marine samples. At the same time, combining high-performance liquid chromatography (HPLC), mass spectrometry (MS), and other technologies, we separate and purify compounds to ensure their high purity and stability.

  • Bioactivity Screening and Identification

We have professional cell culture technology and a high-throughput screening platform, which can conduct comprehensive biological activity screening of the extracted compounds. With the help of an enzyme activity assay and cell permeability membrane test, we further verified the analgesic activity of the compound. Through technical means such as nuclear magnetic resonance (NMR) and mass spectrometry (MS), we can conduct structural identification and analysis of active compounds.

  • Drug Design, Synthesis, and Optimization

Our team uses molecular modeling software and computer-aided drug design (CADD) technology to design and optimize the structure of drug candidates. Through synthetic chemistry technology, we can synthesize and chemically modify drug prodrugs to improve the activity and pharmacokinetic properties of drugs.

  • In Vitro and In Vivo Tests

The analgesic effect and safety of the candidate drugs are further verified through animal models and in vitro experiments. We provide high-resolution in vivo imaging systems and pharmacokinetic analysis to monitor drug distribution and metabolic kinetic processes in the body in real-time, providing reliable data support for further clinical applications.

  • Preclinical Research Support

Our platform enables toxicological assessment and safety studies of drugs. Combined with trial design software and data management systems, it provides comprehensive preclinical research support to ensure the scientificity and compliance of the drug development process.

Reasons to Choose Us

  • Cutting-edge research equipment. To obtain a wide range of samples, our platform is equipped with state-of-the-art collection and extraction instruments.
  • Strong technical support. Our team consists of marine biologists and chemists who can provide customer guidance and assistance.
  • Complete service process. We will design the program according to the different needs of customers to save time.

Related Services & Products

With the deepening of marine drug research, CD BioSciences is leading the field of marine natural products applied to analgesic drug development based on our professional research team and advanced technology. If you would like more information about our services or products, please contact us.


  • Molinski T F, Dalisay D S, Lievens S L, et al. (2009). Drug development from marine natural products[J]. Nature reviews Drug discovery. 8(1): 69-85.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).

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