Development of Marine Cardiovascular Drug

Cardiovascular disease (CVD) is one of the diseases with the greatest impact globally. Recently, bioactive compounds from natural sources such as plants, microorganisms, and marine organisms have attracted widespread interest. Marine sources are a repository of novel bioactive metabolites with various pharmacological activities. Marine species are the newest source of bioactive natural compounds compared to terrestrial plants and non-marine microbes. Marine-derived compounds such as omega-3 ethyl esters, xylketal B, asperlin, and sarinsterol have shown promising results in a variety of CVDs. The importance of marine natural products (MNPs) in drug discovery, especially their role in the creation of existing medicines, is well documented. Natural chemicals have excellent biocompatibility compared to manufactured pharmaceuticals without compromising the diversity of these molecules and their effects. Marine pharmaceuticals are more popular than other products due to their low toxicity, chemical diversity, cost-effectiveness, and proven therapeutic promise.

Fig 1. Possible mechanism of different marine-derived compounds in CVDs. (Akram W, et al., 2023)

Our Services

Through our integrated platform of specialty and medicinal chemistry services, we provide end-to-end solutions for cardiovascular drug development, supporting the isolation, purification, identification and optimization of lead compounds to accelerate the selection of preclinical drug candidates.

• Extraction and Purification of Marine Cardiovascular Drugs
  Marine organism including sponges, tunicates, fish, soft corals, nudibranchs, nudibranchs, hindbranchs, molluscs, echinoderms, bryozoans, shrimps, shells, sea slugs and marine microbes are our biologically active sources of compounds.
• Impurity Isolation and Structure Elucidation of Marine Cardiovascular Drugs
  We isolate and identify impurities/degradants of active compounds by analytical supercritical fluid chromatography-mass spectrometry (SFC-MS) and analytical liquid chromatography-mass spectrometry LC-MS.
• Pharmaceutical Analysis and Quality Control of Marine Cardiovascular Drugs
• Method development and validation
• Characterization of reference materials
• Stability testing, routine sample analysis

Our Purification Capabilities

Our dedicated purification team provides chiral and achiral purification services using preparative supercritical fluid chromatography (Prep-SFC) and preparative high-performance liquid chromatography (prep-HPLC).

• Separation of impurities in starting materials, active compounds and drug products
• Isolation of degradation products of active compounds from forced degradation studies
• Chiral separation method development
• High-throughput purification of isolation compounds

Results and Reports

• Structural determination data
• Custom analysis report
• Experimental procedure
• MS raw data files and MS data quality checks

CD BioSciences is a professional service provider for the marine biology industry. Our marine cardiovascular drug development services can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Reference

• Akram W, Rihan M, Ahmed S, et al. Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry[J]. Marine Drugs, 2023, 21(3): 193.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).