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Marine Collagenases Production

Marine Collagenases Production

Collagenases are proteolytic enzymes that specifically target collagen, breaking it down into smaller peptides and amino acids. Collagenases are capable of cleaving native collagen in vivo and in vitro. Marine collagenases, derived from marine organisms, offer several advantages over their terrestrial counterparts. These enzymes have extensive applications in the field of medical research, pharmaceuticals, cosmetics, and tissue engineering. Collagenases are used in the management of chronic wounds, such as diabetic ulcers and pressure sores. By degrading excessive collagen in the wound bed, collagenases promote the removal of dead tissue, facilitate the formation of granulation tissue, and accelerate wound healing. Collagenases are used to reduce the appearance of wrinkles and fine lines by breaking down collagen in the skin, thereby promoting the synthesis of new collagen and improving skin elasticity. With a unique enzymatic profile, they exhibit enhanced stability, activity, and specificity, making them highly valuable for various applications. At CD BioSciences, we specialize in the production of marine collagenases, utilizing cutting-edge technologies and in-depth expertise to deliver high-quality enzymes for diverse applications.

Our Services

Whether you are looking for biocatalysts to replace chemical synthesis steps, seeking to improve enzyme function, or aiming to reduce manufacturing costs, CD BioSciences' best-in-class features can support your collagenases development.

  • Marine Organism Collection
    We gather a diverse range of marine organisms from various regions, carefully selecting those with a high potential for collagenase production.
  • Assay of Collagenase Activity
    • Rapid assay using Azocoll
    • Sensitive assay using ninhydrin
  • Microbial Growth Measurement
    At CD BioSciences, microbial growth is measured by quantifying extracellular proteins in the medium or intracellular proteins released after sonication.
  • Isolation and Purification of collagenase
    • Ultrafiltration
    • Semi-preparative molecular size exclusion chromatography
    • Cation exchange chromatography
    • Analytical molecular size exclusion chromatography
  • Effect of Assay pH and Temperature on Collagenase Activity
    At CD BioSciences, collagenase activity is measured over a pH range of 4.0 to 9.0 using a sensitive ninhydrin protocol
  • Enzyme Engineering
    To tailor the enzymes for specific applications, we employ protein engineering techniques, including molecular manipulation, mutagenesis, and recombinant protein expression.
  • Marine Collagenase Production
    Our experts utilize state-of-the-art biotechnology techniques to isolate and produce marine collagenases from various marine sources.

Marine Collagenases from Marine Bacteria

Marine Enzyme Types of Marine Bacteria
Marine Collagenases Streptomyces strain
Photorhabdus luminescens
Bacillus subtilis
Pseudoalteromonas agarivorans

Our Capabilities

  • Production efficiency prediction
  • Seamless scaling up from development to manufacturing
  • Capacities from grams to tons
  • Technology transfer with documents and experimental data
  • Complete solutions for large-scale production

CD BioSciences is a professional service provider for the marine biology industry. Our marine collagenase production services can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).

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