Structural Analysis of Marine Polysaccharides

Polysaccharides are essential macromolecules present in almost all living organisms. By acting on cell proliferation and cycle, and regulating different metabolic pathways, marine polysaccharides also have a variety of pharmaceutical activities, such as antioxidant, antibacterial, antiviral, immunostimulatory, anticoagulant and anticancer effects. In addition, these polysaccharides have many general beneficial effects on human health and thus have been developed as potential cosmeceuticals and nutraceuticals. The field of natural polysaccharides of marine origin is already large and expanding. Alginate, agar, agarose and carrageenan are the richest sources of marine polysaccharides. Due to their physicochemical properties, they are easy to be physically and chemically modified to enhance performance, which makes them more widely used in biomedical and pharmaceutical fields. CD BioSciences is a leading provider of structural analysis services for marine polysaccharides. Our cutting-edge methodologies and advanced equipment allow us to elucidate the complex structures of marine polysaccharides.

Fig 1. Marine polysaccharides of interest for cosmeceutical, nutraceutical and pharmacological applications. (Ruocco N, et al., 2016)

Our Services

At CD BioSciences, we aim to provide state-of-the-art structural analysis services for marine polysaccharides. Through our advanced methods, experienced team, and commitment to excellence, we strive to empower researchers in their quest for understanding the complexities of these vital biomolecules.

• Structural Characterization
  Determination of the primary structure of marine polysaccharides through advanced analytical techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.
• Conformational Analysis
  Investigation of the three-dimensional structure and conformational properties of marine polysaccharides. Utilization of techniques like X-ray crystallography, molecular modeling, and advanced spectroscopy to study folding patterns and intermolecular interactions.
• Molecular Weight and Size Determination
  Accurate measurement of the molecular weight and size distribution of marine polysaccharides using gel permeation chromatography (GPC) and other specialized techniques.

Our Analysis Methods

• High performance liquid chromatography
  In polysaccharide analysis, marine polysaccharides are first broken down into smaller fragments using enzymes or hydrochloric acid. These fragments can then be separated by HPLC based on their size and structure and identified using appropriate standards.
• X-ray structure analysis
  Scientists are able to peer inside polysaccharides and gain insight into their structure and function.
• Micro-arrays
  Scientists start by extracting sugar molecules from seawater samples, then feed them into a machine that works a bit like a printer. Because each antibody reacts with only one specific sugar, the researchers could see which monosaccharides were present in the sample.
• At CD BioSciences, we also provide methylation analysis, NMR analysis, Congo red test, UV and FT-IR Spectrum analysis methods for polysaccharides structure analysis.

CD BioSciences is a professional service provider for the marine biology industry. Our structural analysis services of marine polysaccharides can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Reference

• Ruocco N, Costantini S, Guariniello S, et al. Polysaccharides from the marine environment with pharmacological, cosmeceutical and nutraceutical potential[J]. Molecules, 2016, 21(5): 551.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).