Building of Medaka Model

Medaka are primitive vertebrates, but they have several advantages over other model animals. For example, they are fertile and light can control their ovulation. Spawning is frequent and the spawning season is unlimited. Microinjection of fertilized eggs is readily available and relatively inexpensive. Their embryos are transparent, which makes it easy to monitor the dynamic gene expression of various tissues and organs in the body without sacrificing the experimental subjects. Their genomes are about 20% to 40% the size of mammalian genomes, making them the only vertebrates available for large-scale mutagenesis. Their maturation time is only 2-3 months, which is relatively labor-saving and time-saving for the production of transgenic strains. In addition, many conventional techniques of molecular biology and genetics, including knock-in, knock-down, and gene knockout, are well-developed in model fish. Therefore, medaka is a novel and excellent animal system for studying vertebrate-specific in vivo biology.

Four medaka color mutants. (Wakamatsu Y, et al., 2001)

Our Services

CD BioSciences is a contract research organization (CRO) specializing in marine biological research. We provide tailor-made solutions to help pharmaceutical, agrochemical, food, cosmetic companies and academic research institutions accelerate the early development process and add value to medaka.

• Drug development service
  The medaka model not only has the advantages of fast, efficient, and economical in vitro experiments but also has the advantages of strong predictability and high comparability in vivo animal experiments.
• Aging model building service
  Medaka is a novel animal model of aging. Older medaka exhibit human-specific aging changes, such as telomere shortening and mitochondrial damage. CD BioSciences offers medaka model building service for researchers' convenience.
• Vertebrate developmental genetics research service
  Transparent medaka will provide opportunities for non-invasive studies of morphological and molecular events that occur in internal organs later in life.
• Analysis of medaka embryo toxicity service
• Gene editing and functional research service

Advantages of Medaka

• Medaka are small, hardy and prolific. Adult fish are about 3 cm long, weigh 0.3 g, and can tolerate a wide temperature range (4 ℃-40 ℃).
• Since they inhabit stagnant water, aeration and heat tolerance are not required for reproduction. The fact that it was the first vertebrate to successfully reproduce in the microgravity conditions of the space shuttle is a testament to its extraordinary resilience.
• Embryos and chorion are transparent so phenotypes can be easily assessed. Eggs hatch 7 days after fertilization at 25 ℃, and newly hatched fry grow and become sexually mature within 3 months.

CD BioSciences is a professional service provider for the marine biology industry. Our marine medaka model building services can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Reference

• Wakamatsu Y, Pristyazhnyuk S, Kinoshita M, et al. The see-through medaka: a fish model that is transparent throughout life[J]. Proceedings of the National Academy of Sciences, 2001, 98(18): 10046-10050.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).