Development of Marine Antiprotozoal Drug

Protozoan parasites, such as Plasmodium, Trypanosoma, Leishmania, and Toxoplasma, are responsible for various diseases in humans and animals, including malaria, sleeping sickness, leishmaniasis, and toxoplasmosis, respectively. Due to the emergence of antiparasitic resistance, new bioactive compounds are urgently needed to treat neglected tropical diseases. Marine compounds with antiparasitic activity are a potential source of them and offer opportunities to design such drugs. Marine environments are rich sources of natural products with diverse chemical structures and promising biological activities. Using marine biodiversity to discover new medicines has rapidly developed over the past 15 years. Marine antiprotozoal agents have gained significant attention due to their potential in combating parasitic infections caused by protozoan pathogens. CD BioSciences is at the forefront of research and development in marine antiprotozoal agents. Our experienced team of scientists and researchers is dedicated to discovering novel compounds derived from marine sources, exploring their antiprotozoal properties, and developing innovative solutions to combat these pathogens.

Our Services

CD BioSciences has built an industry-leading reputation for successfully delivering top-notch drug development services to organizations of any size. No matter where you are in the preclinical process, or whether you need a complete end-to-end solution, our experts support you every step of the way with purpose, precision and innovation.

• Natural Product Discovery
  We have access to a diverse collection of marine samples, including sponges, corals, algae, and microorganisms. Our team utilizes cutting-edge analytical methods to identify and characterize potential antiprotozoal agents.
• Bioassay Development of Marine Antiprotozoal Agents
  Our experts employ the most appropriate and well-established protozoan models, such as in vitro cultures of Plasmodium falciparum, Trypanosoma brucei, Leishmania donovani, and Toxoplasma gondii, to determine the potency and selectivity of the tested compounds.
• Medicinal Chemistry of Marine Antiprotozoal Agents
  Our team conducts structure-activity relationship (SAR) studies, lead optimization, and synthesis of analogs to enhance the potency, specificity, and bioavailability of potential antiprotozoal agents.
• ADME-Tox Profiling of Marine Antiprotozoal Agents
  We provide comprehensive ADME-Tox profiling services to assess the pharmacokinetic and toxicological properties of marine antiprotozoal compounds. Our experts employ in silico prediction tools, in vitro assays, and preclinical models to evaluate drug-likeness, absorption, distribution, metabolism, elimination, and potential toxicity of lead compounds.
• Drug Development Support
  Our team assists in formulation development, pharmacokinetic studies, safety assessments, and regulatory compliance, helping to advance promising marine antiprotozoal agents toward clinical trials.

Our Technology Platform

• Bioinformatics tools for molecular modeling and virtual screening.
• High-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and liquid chromatography-mass spectrometry (LC-MS) for compound analysis and characterization.
• Drug susceptibility testing and cell-based assays for evaluating anti-tubercular activity.
• In vivo animal models for pharmacokinetic and toxicity studies.
• Advanced drug delivery systems, such as liposomes, nanoparticles, and targeted drug delivery approaches.

CD BioSciences is a professional service provider for the marine biology industry. Our marine antiprotozoal drug development services can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).