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Marine Microbial Production of Lipopeptide Biosurfactant

Lipopeptides are a very prominent class of low molecular weight (LMW) biosurfactants derived from amino acids. These usually cyclic depsipeptides are produced by various microbial clades including Bacillus, Lactobacillus, Streptomyces, Pseudomonas, Serratia, and Firmicutes. The lipopeptides isolated from marine Firmicutes are not exclusively found in marine strains and they were initially isolated from non-marine strains, prior to the identification of their production in marine relatives. Marine organisms are considered a promising source of such natural products. Due to the non-ribosomal origin of lipopeptides, they often contain non-protein amino acids such as the d-enantiomer. Many lipopeptides exhibit not only a reduction in surface tension but also significant biological activity, with the antibiotic daptomycin from Streptomyces roserosa and polymyxin B from Paenibacillus polymyxa being prominent examples. Surfactants produced by different species of Bacillus are considered to be one of the most effective biosurfactants and are said to reduce the surface tension of air/water from 72.5 mN/m to 27 mN/m.

Self-assembly of amphiphilic lipopeptides leads to the formation of micelles with multiple peptides at high density on the surface.Fig. 1 Self-assembly of amphiphilic lipopeptides leads to the formation of micelles with multiple peptides at high density on the surface. (Fujita Y, et al., 2017)

Our Services

CD BioSciences provides one-stop lipopeptide development services. We offer a variety of methods and equipment to choose from to meet your research needs. We offer High-performance thin-layer chromatography (HPTLC) to characterize biosurfactant lipopeptides produced by marine microorganisms. Preparative thin-layer chromatography (TLC) will be performed to purify lipopeptides from crude biosurfactants.

  • Cyclic lipopeptide biosynthesis
  • Linear lipopeptide biosynthesis
  • Cyclic lipopeptide biosynthesis
  • Linear lipopeptide biosynthesis
  • Characterization of linear lipopeptide
  • Cytotoxic activity testing of linear lipopeptide
  • Characterization of cyclic lipopeptide
  • Cytotoxic activity testing cyclic lipopeptide
  • Identification of cyclic lipopeptide
  • Identification of linear lipopeptide
  • Purification of cyclic lipopeptide
  • Purification of linear lipopeptide

Features of Our Services

  • CD BioSciences has professional after-sales service: to provide customers with efficient, fast, practical, and feasible solutions.
  • CD BioSciences has in-depth cooperation with many biological companies and research institutions and has extensive experience in providing quality services for them.
  • CD BioSciences has established a mature technology platform for a variety of applications. We'll help you design the right solution to aid your lipopeptide research.
Our Producing Bacterium Sources

Our Producing Bacterium Sources

The sources of bacterium for lipopeptide biosynthesis are Brevibacterium luteolum, Nocardiopsis alba, Bacillus pumilus, Bacillus stratophericus, Bacillus siamensis, Bacillus circulans, Bacillus licheniformis, Tistrella mobilis, Pontibacter korlensis, and Pseudomonas sp.

Customer Notice

Please let us know the details of your lipopeptide development services and we can provide customized solutions for different projects.

CD BioSciences is a professional service provider for the marine biology industry. Our lipopeptide production services that can ensure that the most suitable methods and techniques are selected for your project. We provide our customers with the most precise ingredient data and highly informed process expertise. Our team of biomass experts plays a key role in the formulation, optimization and commercial evaluation of biomass value-added processes in industry and academia. If necessary, please feel free to contact us.


  • Fujita Y, Taguchi H. Nanoparticle-based peptide vaccines[M]. Micro and Nanotechnology in Vaccine Development. William Andrew Publishing, 2017: 149-170.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).

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